Clustering of PK-trisaccharides on amphiphilic cyclodextrin reveals unprecedented affinity for the Shiga-like toxin Stx2. Issue 76 (11th September 2017)

• Record Type: Journal Article
• Authors: Zhang, Ping; Paszkiewicz, Eugenia; Wang, Qifang; Sadowska, Joanna M.; Kitov, Pavel I.; Bundle, David R.; Ling, Chang-Chun
• Is Part Of: Chemical communications. Volume 53:Issue 76(2017)
• Page Start: 10528
• Page End: 10531
• Publication Date: 2017-09-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c7cc06299k
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Amphiphilic cyclodextrin-based P K -glycoarrays show remarkable binding avidity and selectivity for Stx2 in solid phase assay formats. Abstract : Using amphiphilic cyclodextrin as a scaffold, the first class of P K -glycoconjugates capable of high avidity binding to both Stx1 and Stx2 toxins in solid-phase assay formats is reported. The generated glycomicroarray effectively mimics the plasma membrane surface while discriminating binding of the two Stx toxins, with unprecedented affinity to Stx2.