Clustering of PK-trisaccharides on amphiphilic cyclodextrin reveals unprecedented affinity for the Shiga-like toxin Stx2. Issue 76 (11th September 2017) - Zhang, Ping
Abstract : Amphiphilic cyclodextrin-based P K -glycoarrays show remarkable binding avidity and selectivity for Stx2 in solid phase assay formats. Abstract : Using amphiphilic cyclodextrin as a scaffold, the first class of P K -glycoconjugates capable of high avidity binding to both Stx1 and Stx2 toxins in solid-phase assay formats is reported. The generated glycomicroarray effectively mimics the plasma membrane surface while discriminating binding of the two Stx toxins, with unprecedented affinity to Stx2.