Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum. (November 2017)

• Record Type: Journal Article
• Authors: Huang, Sheng-Zhuo; Ma, Qing-Yun; Kong, Fan-Dong; Guo, Zhi-Kai; Cai, Cai-Hong; Hu, Li-Li; Zhou, Li-Man; Wang, Qi; Dai, Hao-Fu; Mei, Wen-Li; Zhao, You-Xing
• Is Part Of: Phytochemistry. Volume 143(2017)
• Page Start: 104
• Page End: 110
• Publication Date: 2017-11
• Subjects: Ganoderma calidophilum -- Ganodermataceae -- Lanostane triterpenoid -- Cytotoxic activity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2017.07.015
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC50 values of 7.62, 6.28, and 3.55 μ M, respectively. Graphical abstract: Six previously undescribed lanostanoids including four spiro-lactone lanostane triterpenoids (spiroganocalitones A-D) were isolated from fruiting body of Ganoderma calidophilum, together with twenty-three known ones. Ganoderone A showed moderate cytotoxic activity. Highlights: 29 lanostane triterpenoids were isolated from Ganorderma alidophilum. Four of the six previously undescribed lanostanes possess a unique spiro-lactone substructure. Four compounds showed cytotoxic activity against human tumor cell lines. Main compound ganoderone A showed moderate cytotoxic activity.