Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum. (November 2017) - Huang, Sheng-Zhuo
Abstract: To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC50 values of 7.62, 6.28, and 3.55 μ M, respectively. Graphical abstract: Six previously undescribed lanostanoids including four spiro-lactone lanostane triterpenoids (spiroganocalitones A-D) were isolated from fruiting body of Ganoderma calidophilum, together with twenty-three known ones. Ganoderone A showed moderate cytotoxic activity. Highlights: 29 lanostane triterpenoids were isolated from Ganorderma alidophilum. Four of the six previously undescribed lanostanes possess a unique spiro-lactone substructure. Four compounds showed cytotoxic activity against human tumor cell lines. Main compound ganoderone A showed moderate cytotoxic activity.