Synthesis of disulfides tethered pyrroles from β-ketothioamides via a bicyclization/ring-opening/oxidative coupling reaction. Issue 27 (29th June 2017)

• Record Type: Journal Article
• Authors: Li, Cong-Xiang; Liu, Rui-Juan; Yin, Kun; Wen, Li-Rong; Li, Ming
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 27(2017)
• Page Start: 5820
• Page End: 5823
• Publication Date: 2017-06-29
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob00655a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A DABCO-promoted three-component reaction of β-ketothioamides, arylglyoxals and 2-cyanoacetate to construct disulfides tethered pyrroles has been developed. Abstract : A DABCO-promoted three-component reaction of β-ketothioamides (KTAs), arylglyoxals and 2-cyanoacetates to construct disulfides tethered pyrroles by using air as an oxidant has been disclosed. Importantly, this protocol involves a tandem sequence that includes Knoevenagel condensation, Michael addition, N -cyclization, O -cyclization, ring-opening and oxidative coupling.