Synthesis of disulfides tethered pyrroles from β-ketothioamides via a bicyclization/ring-opening/oxidative coupling reaction. Issue 27 (29th June 2017) - Li, Cong-Xiang
Abstract : A DABCO-promoted three-component reaction of β-ketothioamides, arylglyoxals and 2-cyanoacetate to construct disulfides tethered pyrroles has been developed. Abstract : A DABCO-promoted three-component reaction of β-ketothioamides (KTAs), arylglyoxals and 2-cyanoacetates to construct disulfides tethered pyrroles by using air as an oxidant has been disclosed. Importantly, this protocol involves a tandem sequence that includes Knoevenagel condensation, Michael addition, N -cyclization, O -cyclization, ring-opening and oxidative coupling.