A novel two-photon fluorescent probe for hydrogen sulfide in living cells using an acedan–NBD amine dyad based on FRET process with high selectivity and sensitivity. (21st June 2017)

• Record Type: Journal Article
• Authors: Tang, Yao; Jiang, Guo-Fang
• Is Part Of: New journal of chemistry. Volume 41:Number 14(2017)
• Page Start: 6769
• Page End: 6774
• Publication Date: 2017-06-21
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj01080j
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : The first NBD amine based two-photon fluorescence probeL using a FRET strategy was developed for the H2 S detecting in vitro and in vivo . The probeL not only afforded high selectivity and sensitivity for H2 S detecting, but also dispalyed a linear response to H2 S with a low detection limit 24 nM. Abstract : Two-photon imaging, due to its unique advantage to utilize near-infrared light as the excitation source, has emerged as an important tool for biomedical research. Herein, the first NBD amine based two-photon fluorescence probeL using a FRET strategy was developed for detecting H2 S in vitro and in vivo . The probeL not only afforded high selectivity and sensitivity for the detection of H2 S, but also displayed a linear response to H2 S with a low detection limit of 24 nM. Furthermore, the living cell experiments indicated thatL can be effective for the both exogenous and endogenous detection of H2 S inside living cells by two-photon fluorescence imaging.