Genome-Wide Polygenic Scores Predict Reading Performance Throughout the School Years. (4th July 2017)

• Record Type: Journal Article
• Authors: Selzam, Saskia; Dale, Philip S.; Wagner, Richard K.; DeFries, John C.; Cederlöf, Martin; O'Reilly, Paul F.; Krapohl, Eva; Plomin, Robert
• Is Part Of: Scientific studies of reading. Volume 21:Number 4(2017)
• Page Start: 334
• Page End: 349
• Publication Date: 2017-07-04
• Subjects: Reading -- Periodicals; 428.405
• DOI: 10.1080/10888438.2017.1299152
• Languages: English
• ISSNs: 1088-8438

Abstract

ABSTRACT: It is now possible to create individual-specific genetic scores, called genome-wide polygenic scores (GPS). We used a GPS for years of education ( EduYears ) to predict reading performance assessed at UK National Curriculum Key Stages 1 (age 7), 2 (age 12) and 3 (age 14) and on reading tests administered at ages 7 and 12 in a UK sample of 5, 825 unrelated individuals. EduYears GPS accounts for up to 5% of the variance in reading performance at age 14. GPS predictions remained significant after accounting for general cognitive ability and family socioeconomic status. Reading performance of children in the lowest and highest 12.5% of the EduYears GPS distribution differed by a mean growth in reading ability of approximately two school years. It seems certain that polygenic scores will be used to predict strengths and weaknesses in education.