Continuous flow dynamic kinetic resolution of rac-1-phenylethanol using a single packed-bed containing immobilized CAL-B lipase and VOSO4 as racemization catalysts. Issue 3 (1st March 2017)

• Record Type: Journal Article
• Authors: de Miranda, Amanda S.; de M. Silva, Marcus V.; Dias, Fernanda C.; de Souza, Stefania P.; Leão, Raquel A. C.; de Souza, Rodrigo O. M. A.
• Is Part Of: Reaction chemistry & engineering. Volume 2:Issue 3(2017)
• Page Start: 375
• Page End: 381
• Publication Date: 2017-03-01
• Subjects: Reaction mechanisms (Chemistry) -- Periodicals; Chemical engineering -- Periodicals; Chemical engineering; Reaction mechanisms (Chemistry); Periodicals; 547.705
• DOI: 10.1039/c7re00003k
• Languages: English
• ISSNs: 2058-9883

Abstract

Abstract : Herein, we report a method for the continuous flow DKR of rac -1-phenylethanol catalyzed by CAL-B and VOSO4, using a single packed-bed containing both catalysts. Abstract : Herein, we report a method for the continuous flow DKR of rac -1-phenylethanol catalyzed by CAL-B and VOSO4, using a single packed-bed containing both catalysts. Taking advantage of continuous flow techniques to circumvent compatibility issues, the DKR of rac -1-phenylethanol could be performed continuously to give enantiopure ( R )-esters with excellent conversions and high productivities.