Comprehensive phenolic composition analysis and evaluation of Yak-Kong soybean (Glycine max) for the prevention of atherosclerosis. (1st November 2017)

• Record Type: Journal Article
• Authors: Lee, Charles C.; Dudonné, Stéphanie; Dubé, Pascal; Desjardins, Yves; Kim, Jong Hun; Kim, Ji Seung; Kim, Jong-Eun; Park, Jung Han Yoon; Lee, Ki Won; Lee, Chang Yong
• Is Part Of: Food chemistry. Volume 234(2017)
• Page Start: 486
• Page End: 493
• Publication Date: 2017-11-01
• Subjects: Yak-Kong -- Small black soybean -- A-type proanthocyanidins -- Isoflavones -- Atherosclerosis prevention -- Monocyte-endothelial adhesion; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2017.05.012
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Yak-Kong, a small black soybean with a green embryo, is rich in proanthocyanidins. Procyanidin A dimers and phloridzin are newly found in soybean seed coat. Significant amount of coumestrol is found in Yak-Kong soybean embryo. Both Yak-Kong seed coat and embryo attenuated monocyte-endothelial cell adhesion. Abstract: Yak-Kong (YK) ( Glycine max ), a small black soybean cultivar with a green embryo, was evaluated for functional constituents with a focus on atherosclerosis prevention. In comparison to common yellow and black soybean cultivars, YK contains significantly higher concentrations of antioxidants, particularly in its seed coat. A comprehensive phenolic composition analysis revealed that proanthocyanidins were the major phenolic group in YK. In contrast to other proanthocyanidin-rich foods, YK was rich in bioavailable proanthocyanidins (with a degree of polymerization ≤3) specifically with A-type dimers. Significant concentrations of phloridzin and coumestrol were also exclusively found in YK seed coat and the embryo, respectively. Extracts of both the proanthocyanidin-rich seed coat and isoflavonoid-rich embryo of YK attenuated adhesion of THP-1 to LPS-stimulated human umbilical vascular endothelial cells, suggesting that they are important sources of coronary heart disease-preventive phenolics. YK has promising potential for further development as a functional food source targeted at atherosclerosis prevention.