Haw pectin pentaglaracturonide inhibits fatty acid synthesis and improves insulin sensitivity in high-fat-fed mice. (July 2017)

• Record Type: Journal Article
• Authors: Li, Suhong; Huang, Zhu; Dong, Yinping; Zhu, Rugang; Li, Tuoping
• Is Part Of: Journal of functional foods. Volume 34(2017)
• Page Start: 440
• Page End: 446
• Publication Date: 2017-07
• Subjects: Hawthorn -- Pectin pentaglaracturonide -- Sterol regulatory element binding factor -- Fatty acid synthesis -- Insulin sensitivity; HPPS haw pectin pentaglaracturonide -- FAS fatty acid synthase -- ACC acetyl-CoA carboxylase -- G-6-PD glucose-6-phosphate dehydrogenase -- PK pyruvate kinase -- SREBF-1c sterol regulatory element binding factor-1c -- HFC high-fat control -- NC normal control -- TG triglyceride; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.04.030
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: HPPS inhibited fatty acid synthesis. HPPS attenuated high-fat-induced SREBF-1c activation. HPPS improved insulin sensitivity. Abstract: Haw pectin pentaglaracturonide (HPPS) significantly lowered the liver weights, hepatic triglycerides (TG) and total lipid levels of high-fat fed mice compared to those of high-fat control (HFC) mice, after 10 weeks administration. Similarly, high fat diets significantly increased plasma TG, non-esterified fatty acids, glucose, insulin and leptin levels compared to normal control diets, but were significantly decreased by HPPS supplementation after 10 weeks administration, these decreases however were not statistically significant at 4-week, compared to HFC diets. While, HPPS administration significantly increased adiponectin levels whatever at 4-week or 10-week. Further analysis found that HPPS administration significantly attenuated high-fat-induced SREBF-1c activation, decreased the levels of mRNA and protein, and enzyme activities of fatty acid synthase, acetyl-CoA carboxylase, and pyruvate kinase in the livers of mice compared to the high-fat control group. Moreover, prolonged administration of HPPS appeared to be more effective to achieve the above changes.