Copper-catalyzed oxidative decarboxylative coupling of α-keto acids and sulfoximines. Issue 20 (4th May 2017)

• Record Type: Journal Article
• Authors: Pimpasri, Chaleena; Sumunnee, Ladawan; Yotphan, Sirilata
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 20(2017)
• Page Start: 4320
• Page End: 4327
• Publication Date: 2017-05-04
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob00776k
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The formation of N -aroylsulfoximines via a copper-catalyzed oxidative decarboxylative coupling of α-keto acids with NH -sulfoximines is reported. Abstract : A copper-catalyzed oxidative decarboxylative coupling of α-keto acids with NH -sulfoximines has been developed. With CuBr as the catalyst and K2 S2 O8 as the oxidant, this reaction enables the formation of a C–N bond and gives N -aroylsulfoximine products in moderate to excellent yields. The reaction mechanism is likely to involve the generation of a reactive aroyl radical intermediate.