Copper-catalyzed oxidative decarboxylative coupling of α-keto acids and sulfoximines. Issue 20 (4th May 2017) - Pimpasri, Chaleena
Abstract : The formation of N -aroylsulfoximines via a copper-catalyzed oxidative decarboxylative coupling of α-keto acids with NH -sulfoximines is reported. Abstract : A copper-catalyzed oxidative decarboxylative coupling of α-keto acids with NH -sulfoximines has been developed. With CuBr as the catalyst and K2 S2 O8 as the oxidant, this reaction enables the formation of a C–N bond and gives N -aroylsulfoximine products in moderate to excellent yields. The reaction mechanism is likely to involve the generation of a reactive aroyl radical intermediate.