Front cover: A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane‐treated colon cancer cells. Issue 4 (April 2017)

• Record Type: Journal Article
• Authors: Johnson, Gavin S.; Li, Jia; Beaver, Laura M.; Dashwood, W. Mohaiza; Sun, Deqiang; Rajendran, Praveen; Williams, David E.; Ho, Emily; Dashwood, Roderick H.
• Is Part Of: Molecular nutrition & food research. Volume 61:Issue 4(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-04
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201770041
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Mol. Nutr. Food Res . 2017, 61, 1600769. DOI:10.1002/mnfr.201600769 Pseudogenes have been viewed, historically, as nonfunctional DNA sequences with close homology to other functional protein‐coding genes. NmrA‐like redox sensor 2 ( NMRAL2P ) is a novel functional pseudogene, the first to be identified both as a direct transcriptional target of Nrf2, and as a downstream co‐regulator of Nrf2‐dependent gene activation in response to sulforaphane treatment.