Residue analysis of tetracyclines in milk by HPLC coupled with hollow fiber membranes-based dynamic liquid-liquid micro-extraction. (1st October 2017)

• Record Type: Journal Article
• Authors: Xu, Hui; Mi, Hong-Yu; Guan, Ming-Ming; Shan, Hong-Yan; Fei, Qiang; Huan, Yan-Fu; Zhang, Zhi-Quan; Feng, Guo-Dong
• Is Part Of: Food chemistry. Volume 232(2017)
• Page Start: 198
• Page End: 202
• Publication Date: 2017-10-01
• Subjects: Tetracycline (PubChem CID: 54675776) -- Oxytetracycline (PubChem CID: 54675779) -- Chlorotetracycline (PubChem CID: 54675777) -- Doxycycline (PubChem CID: 54671203); Dynamic liquid-liquid micro-extraction -- Hollow fiber membrane -- Ionic liquid -- Milk -- Tetracyclines; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2017.04.021
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: A dynamic extraction method was used for the detection of tetracyclines in milk. The automatic processes of extraction and desorption simplified the operation. The membrane barrier has been avoided. The analytes can be extracted directly without deproteinization and degreasing. The available area of membrane is expanded. Abstract: A novel hollow fiber membranes-based dynamic liquid-liquid micro-extraction (HF-DLLME) coupled with HPLC-UV detection has been developed for the residue analysis of tetracyclines in milk samples without deproteinization and degreasing. The influences of experimental parameters were investigated and optimized. The method showed a good performance. The limits of detection (LOD) are in the range of 0.95–3.6 μg/L. The recoveries in spiked samples range from 92.38 to 107.3%. The relative standard deviations (RSDs) are lower than 8.66%. The advantages of this method are simple operation, high efficiency, absence of sample carryover and low cost.