Lanostane-type triterpenoids from Kadsura coccinea. Issue 20 (18th May 2017)

• Record Type: Journal Article
• Authors: Hu, Zheng-Xi; Li, Xiao-Nian; Shi, Yi-Ming; Wang, Wei-Guang; Du, Xue; Li, Yan; Zhang, Yong-Hui; Pu, Jian-Xin; Sun, Han-Dong
• Is Part Of: Tetrahedron. Volume 73:Issue 20(2017)
• Page Start: 2931
• Page End: 2937
• Publication Date: 2017-05-18
• Subjects: Kadsura coccinea -- Lanostane-type triterpenoids -- Cytotoxicity; LGYHQPQOXJOAQF-MUUZAPTASA-N; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2017.03.087
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: Systematic phytochemical investigation on the stems of Kadsura coccinea resulted in the isolation of eleven new lanostane-type triterpenoids, named kadcoccinones G–Q (1 –11 ), together with two known structural analogues, kadpolysperin M (12 ) and abiesatrine D (13 ). Their structures were characterized on the basis of comprehensive spectroscopic methods, and the absolute configuration of1 was ascertained by single-crystal X-ray diffraction. Structurally, compounds1 /2, 4 /5, and6 /7 were three pairs of C-12 epimers, respectively. Additionally, compounds1 –11 were evaluated for their in vitro cytotoxicity against the human tumor HL-60, SMMC-772, A-549, MCF-7, SW-480, and HeLa cell lines using the MTS viability assay. Graphical abstract: Highlights: Eleven new lanostane-type triterpenoids (1 –11 ) were isolated from the stems of Kadsura coccinea. The absolute configuration of compound1 was determined by single-crystal X-ray diffraction. Compounds1 /2, 4 /5, and6 /7 were three pairs of C-12 epimers, respectively. Compounds1 –11 were evaluated for their in vitro cytotoxicity.