Lanostane-type triterpenoids from Kadsura coccinea. Issue 20 (18th May 2017) - Hu, Zheng-Xi
Abstract: Systematic phytochemical investigation on the stems of Kadsura coccinea resulted in the isolation of eleven new lanostane-type triterpenoids, named kadcoccinones G–Q (1 –11 ), together with two known structural analogues, kadpolysperin M (12 ) and abiesatrine D (13 ). Their structures were characterized on the basis of comprehensive spectroscopic methods, and the absolute configuration of1 was ascertained by single-crystal X-ray diffraction. Structurally, compounds1 /2, 4 /5, and6 /7 were three pairs of C-12 epimers, respectively. Additionally, compounds1 –11 were evaluated for their in vitro cytotoxicity against the human tumor HL-60, SMMC-772, A-549, MCF-7, SW-480, and HeLa cell lines using the MTS viability assay. Graphical abstract: Highlights: Eleven new lanostane-type triterpenoids (1 –11 ) were isolated from the stems of Kadsura coccinea. The absolute configuration of compound1 was determined by single-crystal X-ray diffraction. Compounds1 /2, 4 /5, and6 /7 were three pairs of C-12 epimers, respectively. Compounds1 –11 were evaluated for their in vitro cytotoxicity.