Antioxidants and α-glucosidase inhibitors from "Liucha" (young leaves and shoots of Sibiraea laevigata). (1st September 2017)

• Record Type: Journal Article
• Authors: Zhao, Jian-Qiang; Wang, Yan-Ming; Yang, Yan-Long; Zeng, Ying; Mei, Li-Juan; Shi, Yan-Ping; Tao, Yan-Duo
• Is Part Of: Food chemistry. Volume 230(2017)
• Page Start: 117
• Page End: 124
• Publication Date: 2017-09-01
• Subjects: Sibiraea laevigata -- Sorbitol O-caffeic acid ester derivatives -- Phenolic compounds -- Antioxidants -- α-Glucosidase inhibitors; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2017.03.024
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Twenty-five phenolic compounds were isolated and identified from "Liucha". Twenty-three compounds were reported from Sibiraea laevigata for the first time. Phenolic compounds showed potent α -glucosidase inhibition and antioxidant activities. Sorbitol ester F showed the best α -glucosidase inhibitory activity in vitro . Abstract: The young leaves and shoots of Sibiraea laevigata, known as "Liucha", are used as tea by Tibetans to improve digestion after meals. Long-term consumption of "Liucha" will cause weight loss. In present work, we reported on the isolation and NMR and chemical analysis-based elucidation of seven new sorbitol O -caffeic acid ester derivatives named sorbitol esters A–G (1 –7 ) and eighteen known phenolic compounds from S. laevigata . All of the isolates were evaluated for their antioxidant and α -glucosidase inhibitory activities. Among them sorbitol ester A (1 ), sorbitol ester D (4 ), sorbitol ester F (6 ), sorbitol ester G (7 ), isoferulic acid (15 ), methyl caffeate (18 ), trans - p -hydroxycinnamic acid (19 ), and kaempferol 3- O - β -d -(6″- E - p -coumaroyl)-glucopyranoside (25 ) showed more potent α -glucosidase inhibitory activity than the clinical drug acarbose.