Determination of hymexazol in 26 foods of plant origin by modified QuEChERS method and liquid chromatography tandem-mass spectrometry. (1st August 2017)

• Record Type: Journal Article
• Authors: Jiang, Zejun; Li, Hui; Cao, Xiaolin; Du, Pengfei; Shao, Hua; Jin, Fen; Jin, Maojun; Wang, Jing
• Is Part Of: Food chemistry. Volume 228(2017)
• Page Start: 411
• Page End: 419
• Publication Date: 2017-08-01
• Subjects: Hymexazol (PubChem CID: 24781) -- Magnesium sulfate (PubChem CID: 24083) -- Ammonium acetate (PubChem CID: 517165) -- Formic acid (PubChem CID: 284) -- Acetonitrile (PubChem CID: 6342) -- Sodium chloride (PubChem CID: 5234); ACN acetonitrile -- Al2O3 neutral aluminium oxide -- C18 octadecylsilyl -- CAD collision gas -- CE collision energy -- CUR curtain gas -- CXP collision cell exit potential -- DP declustering potential -- EP entrance potential -- EU European Union -- FA formic acid -- GCB graphitized carbon black -- GC-FPD gas chromatography with flame photometric detector -- GC–MS gas chromatography–mass spectrometry -- GC-NPD gas chromatography with nitrogen phosphorus detector -- GS1 atomization air pressure -- GS2 auxiliary gas -- HILIC hydrophilic interaction liquid chromatography -- IS ion spray voltage -- LC–ESI-MS/MS liquid chromatography tandem-mass spectrometry with electrospray ionization -- LOQ limit of quantitation -- ME matrix effects -- MgSO4 magnesium sulfate -- MRLs Maximum residue limits -- MRM multiple reaction monitoring -- MWCNTs multi-walled carbon nanotubes -- NaCl sodium chloride -- NH4AC ammonium acetate -- PEP-2 polar enhanced polymer-2 -- PSA primary secondary amine -- PVPP polyvinylpolypyrrolidone -- QuEChERS Quick Easy Cheap Effective Rugged and Safe -- RSD relative standard deviation -- TEM source temperature -- UPLC-DAD ultra-high performance liquid chromatography with diode-array detector; Hymexazol residue -- Foods of plant origin -- QuEChERS -- LC–MS/MS -- Matrix-matched calibration; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2017.02.014
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: A LC–MS/MS method based on modified QuEChERS was developed for hymexazol analysis. Matrix-matched standards were adopted to compensate for the matrix effect. The method was validated with good accuracy and precision in all matrices. The method was simple, fast, sensitive, dependable, and effective. The method was applied for monitoring hymexazol residues in 26 kinds of foods of plant origin. Abstract: A rapid and sensitive method based on modified QuEChERS for hymexazol determination in 26 plant-derived foods using liquid chromatography tandem-mass spectrometry (LC-MS/MS) was developed. Variables affecting the separation (LC column, mobile phase additives) and clean-up effects of various dispersive phases, such as PSA, C18, GCB, MWCNTs, PEP-2, Al2 O3, Florisil, and PVPP were evaluated. The method was validated using 26 matrices at spiked levels of 0.01 or 0.02, 0.05, 0.1, and 0.5 mg/kg (0.05, 0.2, 0.5, and 1.0 mg/kg for green tea). Mean recoveries were between 71.2% and 113.8%, and intra and inter-day precisions were below 14.8%. The limit of quantitation for 26 matrices ranged from 10 to 50 μg/kg. Matrix-matched calibration was used. The method was subsequently applied for real sample analysis, and hymexazol was detected in a cucumber (below the LOQ) and was not detected in any other sample. The method is simple and effective, and meets the routine monitoring requirements for hymexazol residue in foods.