A diet with lactosucrose supplementation ameliorates trinitrobenzene sulfonic acid-induced colitis in rats. Issue 1 (4th November 2014)

• Record Type: Journal Article
• Authors: Zhou, Yan; Ruan, Zheng; Zhou, Xiaoli; Huang, Xiaoliu; Li, Hua; Wang, Ling; Zhang, Cui; Liu, Shiqiang; Deng, Zeyuan; Wu, Guoyao; Yin, Yulong
• Is Part Of: Food & function. Volume 6:Issue 1(2015)
• Page Start: 161
• Page End: 171
• Publication Date: 2014-11-04
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/c4fo00381k
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : Chronic intestinal inflammation contributes to an increased risk of colon cancer. Abstract : Chronic intestinal inflammation contributes to an increased risk of colon cancer. Lactosucrose (LS), a kind of functional trisaccharide, can modulate immunity and promote microbe growth. The aim of this study was to investigate the effect of LS on 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) induced colitis in rats. Rats were randomly divided into four treatment groups: the normal group, TNBS group, LS group, and salicylazosulfapyridine (SASP) group for five weeks. LS supplementation ameliorated TNBS-induced colitis. LS supplementation increased IL-10 production and suppressed the secretion of IL-12 in the colon, as compared to the TNBS group. LS decreased the production of TLR-2 protein and nuclear NF-κB p65 protein, as well as mRNA levels, as compared with colitic rats. These results indicate that chronic feeding of LS inhibited TNBS-induced chronic inflammation. LS has potential nutraceutical intervention to combat colitis.