Recording the dynamic endocytosis of single gold nanoparticles by AFM-based force tracing. Issue 17 (13th April 2015)

• Record Type: Journal Article
• Authors: Ding, Bohua; Tian, Yongmei; Pan, Yangang; Shan, Yuping; Cai, Mingjun; Xu, Haijiao; Sun, Yingchun; Wang, Hongda
• Is Part Of: Nanoscale. Volume 7:Issue 17(2015)
• Page Start: 7545
• Page End: 7549
• Publication Date: 2015-04-13
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c5nr01020a
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : By using a force tracing technique, the dynamic process of gold nanoparticle endocytosis is recorded at the single-particle and microsecond level unprecedentedly. Abstract : We utilized force tracing to directly record the endocytosis of single gold nanoparticles (Au NPs) with different sizes, revealing the size-dependent endocytosis dynamics and the crucial role of membrane cholesterol. The force, duration and velocity of Au NP invagination are accurately determined at the single-particle and microsecond level unprecedentedly.