Recording the dynamic endocytosis of single gold nanoparticles by AFM-based force tracing. Issue 17 (13th April 2015) - Ding, Bohua
Abstract : By using a force tracing technique, the dynamic process of gold nanoparticle endocytosis is recorded at the single-particle and microsecond level unprecedentedly. Abstract : We utilized force tracing to directly record the endocytosis of single gold nanoparticles (Au NPs) with different sizes, revealing the size-dependent endocytosis dynamics and the crucial role of membrane cholesterol. The force, duration and velocity of Au NP invagination are accurately determined at the single-particle and microsecond level unprecedentedly.