An expedient microwave assisted regio- and stereoselective synthesis of spiroquinoxaline pyrrolizine derivatives and their AChE inhibitory activity. (5th January 2017)

• Record Type: Journal Article
• Authors: Akondi, Adinarayana Murthy; Mekala, Sowmya; Kantam, Mannepalli Lakshmi; Trivedi, Rajiv; Raju Chowhan, L.; Das, Amitava
• Is Part Of: New journal of chemistry. Volume 41:Number 2(2017)
• Page Start: 873
• Page End: 878
• Publication Date: 2017-01-05
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c6nj02869a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : We report here an efficient protocol for the one-pot facile synthesis of spiro[indeno[1, 2- b ]quinoxaline-11, 3′-pyrrolizine]heterocyclic scaffolds and their AChE inhibitory studies. Abstract : In this study, we report an efficient four-component cascade protocol to afford spiro indeno[1, 2- b ]quinoxaline-11, 3′-pyrrolizines via the condensation of ninhydrin, phenylenediamine, proline, and nitrostyrene derivatives under microwave irradiation and classical conditions. The 1, 3-dipolar cycloaddition reaction was found to proceed in a highly regio- and stereoselective manner. This methodology exemplifies the green chemistry protocol for the preparation of spiro-pyrrolizines. In addition, all the synthesized compounds were screened for AChE inhibitory activity and 6 out of 21 compounds depicted significant activity in the low micromolar IC50 range.