An expedient microwave assisted regio- and stereoselective synthesis of spiroquinoxaline pyrrolizine derivatives and their AChE inhibitory activity. (5th January 2017) - Akondi, Adinarayana Murthy
Abstract : We report here an efficient protocol for the one-pot facile synthesis of spiro[indeno[1, 2- b ]quinoxaline-11, 3′-pyrrolizine]heterocyclic scaffolds and their AChE inhibitory studies. Abstract : In this study, we report an efficient four-component cascade protocol to afford spiro indeno[1, 2- b ]quinoxaline-11, 3′-pyrrolizines via the condensation of ninhydrin, phenylenediamine, proline, and nitrostyrene derivatives under microwave irradiation and classical conditions. The 1, 3-dipolar cycloaddition reaction was found to proceed in a highly regio- and stereoselective manner. This methodology exemplifies the green chemistry protocol for the preparation of spiro-pyrrolizines. In addition, all the synthesized compounds were screened for AChE inhibitory activity and 6 out of 21 compounds depicted significant activity in the low micromolar IC50 range.