(O, O-Dibutyl)-O-1-trifluoromethyl-2, 2, 2-trifluoroethyl phosphate (BFP): A selective inhibitor of mouse plasma carboxylesterase. (1st December 2016)

• Record Type: Journal Article
• Authors: Makhaeva, Galina F.; Rudakova, Elena V.; Aksinenko, Alexey Yu.; Sokolov, Vladimir B.; Richardson, Rudy J.
• Is Part Of: Phosphorus, sulfur, and silicon and the related elements. Volume 191:Number 11/12(2016)
• Page Start: 1589
• Page End: 1590
• Publication Date: 2016-12-01
• Subjects: (O, O-dibutyl)-O-1-trifluoromethyl-2, 2, 2-trifluoroethyl phosphate -- carboxylesterase -- selective inhibitor -- mouse blood; Sulfur compounds -- Periodicals; Organosulfur compounds -- Periodicals; Phosphorus compounds -- Periodicals; Organophosphorus compounds -- Periodicals; Silicon compounds -- Periodicals; Organosilicon compounds -- Periodicals; 546
• DOI: 10.1080/10426507.2016.1216423
• Languages: English
• ISSNs: 1042-6507

Abstract

GRAPHICAL ABSTRACT: ABSTRACT: A comparative analysis of acetylcholinesterase, butyrylcholinesterase, and carboxylesterase inhibition by ( O, O -dibutyl)- O -1-trifluoromethyl-2, 2, 2-trifluoroethyl phosphate (BFP) in vitro in hemolysed mouse blood preparations and in vivo 1 h after i.p. injections of BFP at increasing doses was performed. BFP was shown to be an effective and selective mouse blood CaE inhibitor both in vitro and in vivo . The time course of blood CaE inhibition demonstrated deep inhibition during 6–7 h.