(O, O-Dibutyl)-O-1-trifluoromethyl-2, 2, 2-trifluoroethyl phosphate (BFP): A selective inhibitor of mouse plasma carboxylesterase. (1st December 2016) - Makhaeva, Galina F.
GRAPHICAL ABSTRACT: ABSTRACT: A comparative analysis of acetylcholinesterase, butyrylcholinesterase, and carboxylesterase inhibition by ( O, O -dibutyl)- O -1-trifluoromethyl-2, 2, 2-trifluoroethyl phosphate (BFP) in vitro in hemolysed mouse blood preparations and in vivo 1 h after i.p. injections of BFP at increasing doses was performed. BFP was shown to be an effective and selective mouse blood CaE inhibitor both in vitro and in vivo . The time course of blood CaE inhibition demonstrated deep inhibition during 6–7 h.