Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi. Issue 70 (11th July 2016)

• Record Type: Journal Article
• Authors: Zhang, Zhongyin; Yang, Fan; Fu, Jian-Jun; Shen, Yun-Heng; He, Weiwei; Zhang, Wei-Dong
• Is Part Of: RSC advances. Volume 6:Issue 70(2016)
• Page Start: 65885
• Page End: 65888
• Publication Date: 2016-07-11
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra11915h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Delavatine A, a cytotoxic alkaloid with a unique cyclopenta[ de ]isoquinoline core, was isolated from I. delavayi . Abstract : Natural products have long been an important source for the discovery of biologically active compounds, in particular, drug leads. Delavatine A (1 ), a structurally unusual cyclopenta[ de ]isoquinoline alkaloid, was isolated from Incarvillea delavayi . Extensive spectroscopic analysis, in combination with biogenetic speculation, established the structure of1 . Delavatine A (1 ) exhibited considerable cytotoxicity against a number of cancer cell lines with IC50 values in the range of 4.28 to 6.61 μg mL −1 .