Delavatine A, a structurally unusual cyclopenta[de]isoquinoline alkaloid from Incarvillea delavayi. Issue 70 (11th July 2016) - Zhang, Zhongyin
Abstract : Delavatine A, a cytotoxic alkaloid with a unique cyclopenta[ de ]isoquinoline core, was isolated from I. delavayi . Abstract : Natural products have long been an important source for the discovery of biologically active compounds, in particular, drug leads. Delavatine A (1 ), a structurally unusual cyclopenta[ de ]isoquinoline alkaloid, was isolated from Incarvillea delavayi . Extensive spectroscopic analysis, in combination with biogenetic speculation, established the structure of1 . Delavatine A (1 ) exhibited considerable cytotoxicity against a number of cancer cell lines with IC50 values in the range of 4.28 to 6.61 μg mL −1 .