Discovery of aromadendrane anologues from the marine-derived fungus Scedosporium dehoogii F41-4 by NMR-guided isolation. Issue 97 (4th October 2016)

• Record Type: Journal Article
• Authors: Hu, Kun-Chao; Xu, Meng-Yang; Li, Hou-Jin; Yuan, Jie; Tang, Ge; Xu, Jun; Yang, De-Po; Lan, Wen-Jian
• Is Part Of: RSC advances. Volume 6:Issue 97(2016)
• Page Start: 94763
• Page End: 94770
• Publication Date: 2016-10-04
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra21142a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Six new aromadendrane sesquiterpenoids and two known analogues, together with a new polyketide were discovered from the marine-derived fungus Scedosporium dehoogii by NMR-guided isolation. The biosynthetic pathways of sesquiterpenoids were proposed. Abstract : Eight closely biogenetically-related aromadendrane-type sesquiterpenoids, six of them new, scedogiines A–F (1–3, 6–8 ), together with a new polyketide scedogiine G (9 ) were discovered from the culture broth of the marine-derived fungus Scedosporium dehoogii F41-4 by NMR-guided isolation. Their structures were determined from extensive NMR and HR-ESI-MS data. The absolute configurations of the new sesquiterpenoids were elucidated by ECD calculation. Plausible biogenetic pathways of the aromadendrane analogues were postulated.