Discovery of aromadendrane anologues from the marine-derived fungus Scedosporium dehoogii F41-4 by NMR-guided isolation. Issue 97 (4th October 2016) - Hu, Kun-Chao
Abstract : Six new aromadendrane sesquiterpenoids and two known analogues, together with a new polyketide were discovered from the marine-derived fungus Scedosporium dehoogii by NMR-guided isolation. The biosynthetic pathways of sesquiterpenoids were proposed. Abstract : Eight closely biogenetically-related aromadendrane-type sesquiterpenoids, six of them new, scedogiines A–F (1–3, 6–8 ), together with a new polyketide scedogiine G (9 ) were discovered from the culture broth of the marine-derived fungus Scedosporium dehoogii F41-4 by NMR-guided isolation. Their structures were determined from extensive NMR and HR-ESI-MS data. The absolute configurations of the new sesquiterpenoids were elucidated by ECD calculation. Plausible biogenetic pathways of the aromadendrane analogues were postulated.