Activation and recruitment of brown adipose tissue by cold exposure and food ingredients in humans. Issue 4 (August 2016)

• Record Type: Journal Article
• Authors: Saito, Masayuki; Yoneshiro, Takeshi; Matsushita, Mami
• Is Part Of: Best practice & research. Volume 30:Issue 4(2016)
• Page Start: 537
• Page End: 547
• Publication Date: 2016-08
• Subjects: brown adipose tissue -- capsinoids -- catechins -- cold exposure -- obesity -- transient receptor potential channels; βAR β-adrenergic receptor -- BAT brown adipose tissue -- CIT cold-induced thermogenesis -- COMT catechol-O-methyl transferase -- CT computed tomography -- D2 type II deiodinase -- DIT diet-induced thermogenesis -- EE energy expenditure -- FDG fluorodeoxyglucose -- GP Grains of Paradise -- NST non-shivering metabolic thermogenesis -- PET positron emission tomography -- TRP transient receptor potential channel -- TRPV1 TRP vanilloid 1 -- UCP1 uncoupling protein 1 -- WAT white adipose tissue; Endocrine glands -- Diseases -- Periodicals; Metabolism -- Disorders -- Periodicals; Endocrinology -- Periodicals; Metabolism -- Periodicals; 616.4
• DOI: 10.1016/j.beem.2016.08.003
• Languages: English
• ISSNs: 1521-690X

Abstract

Abstract : Since the recent re-discovery of brown adipose tissue (BAT) in adult humans, this thermogenic tissue has attracted increasing interest. The inverse relationship between the BAT activity and body fatness suggests that BAT, because of its energy dissipating activity, is protective against body fat accumulation. Cold exposure activates and recruits BAT in association with increased energy expenditure and decreased body fatness. The stimulatory effects of cold are mediated through transient receptor potential channels (TRP), most of which are also chemesthetic receptors for various food ingredients. In fact, capsaicin and its analog capsinoids, representative agonists of TRPV1, mimic the effects of cold to decrease body fatness through the activation and recruitment of BAT. The anti-obesity effect of some other food ingredients including tea catechins may also be attributable to the activation of the TRP-BAT axis. Thus, BAT is a promising target for combating obesity and related metabolic disorders in humans.