Bioactivity-guided isolation of new antiproliferative compounds from Juniperus foetidissima Willd. Issue 17 (1st September 2016)

• Record Type: Journal Article
• Authors: Rafieian-kopaei, Mahmood; Suleimani dehkordi, Ibrahim; Ghanadian, Mustafa; Shokrollahi, Ardeshir; Aghaei, Mahmoud; Syed Majid, Ayatollahi; Choudhary, M. Iqbal
• Is Part Of: Natural product research. Volume 30:Issue 17(2016)
• Page Start: 1927
• Page End: 1933
• Publication Date: 2016-09-01
• Subjects: Cupressaceae -- Juniperus foetidissima -- cytotoxicity -- ovary cancer cell -- bladder cancer cell; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1101106
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Based on a literature survey on cytotoxic medicinal plants, Juniper species were identified as interesting source of antitumor compounds. Using bioassay-guided fractionation against Caov-4 cancer cells on acetone extract of leaves and branchlets of Juniperus foetidissima led to the isolation of a new 3H-benzofuaran-2-one: 4-methyl-3-methoxy-3H-benzofuaran-2-one (1 ), a new sesquiterpene: 4, 9(α)-dihydroxy-nardosin-6-en (2 ) and an already known labdane-type diterpene: 15-hydroxy-8(17), 13(E)-labdadiene-19-carboxilic acid (3 ). Compounds1–3 exhibited cytotoxic effects, with moderate cytotoxicity against the EJ-138 bladder and CAOV-4 ovary cancer cell lines. Abstract :