Bioactivity-guided isolation of new antiproliferative compounds from Juniperus foetidissima Willd. Issue 17 (1st September 2016) - Rafieian-kopaei, Mahmood
Abstract: Based on a literature survey on cytotoxic medicinal plants, Juniper species were identified as interesting source of antitumor compounds. Using bioassay-guided fractionation against Caov-4 cancer cells on acetone extract of leaves and branchlets of Juniperus foetidissima led to the isolation of a new 3H-benzofuaran-2-one: 4-methyl-3-methoxy-3H-benzofuaran-2-one (1 ), a new sesquiterpene: 4, 9(α)-dihydroxy-nardosin-6-en (2 ) and an already known labdane-type diterpene: 15-hydroxy-8(17), 13(E)-labdadiene-19-carboxilic acid (3 ). Compounds1–3 exhibited cytotoxic effects, with moderate cytotoxicity against the EJ-138 bladder and CAOV-4 ovary cancer cell lines. Abstract :