Inside front cover: Comparison of anti‐inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis. Issue 9 (September 2016)

• Record Type: Journal Article
• Authors: Kim, Hyemee; Banerjee, Nivedita; Ivanov, Ivan; Pfent, Catherine M.; Prudhomme, Kalan R.; Bisson, William H.; Dashwood, Roderick H.; Talcott, Stephen T.; Mertens‐Talcott, Susanne U.
• Is Part Of: Molecular nutrition & food research. Volume 60:Issue 9(2016)
• Page Start: NA
• Page End: NA
• Publication Date: 2016-09
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201670094
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Mol. Nutr. Food Res . 2016, 60, 1912–1923. DOI:10.1002/mnfr.201501008 Mango beverage (rich in gallotannins) inhibits the IGF‐1R‐AKT/mTOR axis, and pomegranate beverage (rich in ellagitannins) downregulates the mTOR downstream pathway through reduction of ERK1/2 in DSS‐treated rats. Gallic and ellagic acid are predicted in silico to bind to specific targets, such as IGF‐1R and EGFR.