Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?. Issue 32 (6th June 2016)

• Record Type: Journal Article
• Authors: Cheignon, Clémence; Collin, Fabrice; Faller, Peter; Hureau, Christelle
• Is Part Of: Dalton transactions. Volume 45:Issue 32(2016)
• Page Start: 12627
• Page End: 12631
• Publication Date: 2016-06-06
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c6dt01979j
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : At low concentration, ascorbate promotes oxidative damage via Cu(Aβ) induced ROS production while at high concentration it can prevent oxidation of biological targets other than Aβ itself. Abstract : Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Aβ) induced reactive oxygen species production in the context of Alzheimer's disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-β peptide itself.