Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?. Issue 32 (6th June 2016) - Cheignon, Clémence
Abstract : At low concentration, ascorbate promotes oxidative damage via Cu(Aβ) induced ROS production while at high concentration it can prevent oxidation of biological targets other than Aβ itself. Abstract : Evaluation of the pro versus antioxidant activity of ascorbate regarding Cu(Aβ) induced reactive oxygen species production in the context of Alzheimer's disease shows that a protective activity can only be observed at high ascorbate concentration for exogenous molecules but not for the amyloid-β peptide itself.