New cytotoxic constituents from the Red Sea soft coral Nephthea sp. Issue 11 (2nd June 2016)

• Record Type: Journal Article
• Authors: Hegazy, Mohamed-Elamir F.; Gamal-Eldeen, Amira M.; Mohamed, Tarik A.; Alhammady, Montaser A.; Hassanien, Abuzeid A.; Shreadah, Mohamed A.; Abdelgawad, Ibrahim I.; Elkady, Eman M.; Paré, Paul W.
• Is Part Of: Natural product research. Volume 30:Issue 11(2016)
• Page Start: 1266
• Page End: 1272
• Publication Date: 2016-06-02
• Subjects: Nephthea sp. -- terpenes -- cytotoxicity -- breast cancer cell line MCF-7; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2015.1055266
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract : Nephthea are soft coral species rich in sesquiterpenoids and steroids. An organic extract of Nephthea sp. resulted in the isolation of a new steroid (1 ), as well as several previously reported metabolites (2 –9 ). Structures were elucidated by employing NMR and HR-EI-MS analyses. The total extract, fractions and purified compounds exhibited differential cytotoxicity against the breast cancer MCF-7 cell line. Abstract :