A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds. Issue 63 (18th July 2016)

• Record Type: Journal Article
• Authors: Firth, James D.; Craven, Philip G. E.; Lilburn, Matthew; Pahl, Axel; Marsden, Stephen P.; Nelson, Adam
• Is Part Of: Chemical communications. Volume 52:Issue 63(2016)
• Page Start: 9837
• Page End: 9840
• Publication Date: 2016-07-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc04662b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A synthetic approach to diverse natural product-like scaffolds was developed that was broadly inspired by diterpene biosynthesis. Abstract : A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.