A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds. Issue 63 (18th July 2016) - Firth, James D.
Abstract : A synthetic approach to diverse natural product-like scaffolds was developed that was broadly inspired by diterpene biosynthesis. Abstract : A synthetic approach to diverse scaffolds was developed that was inspired by diterpene biosynthesis. Initial scaffolds, generated using Diels–Alder reactions of furyl-functionalised amines, were transformed into alternative scaffolds using cleavage, ring expansion, annulation and rearrangement reactions. In total, 25 diverse scaffolds were prepared that were shown to have high natural product-likeness.