Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats. Issue 7 (1st June 2016)

• Record Type: Journal Article
• Authors: Park, Chan Hum; Lee, Joo Young; Kim, Min Yeong; Shin, Sung Ho; Roh, Seong-Soo; Choi, Jae Sue; Chung, Hae Young; Song, Yeong-Ok; Shin, Yu Su; Yokozawa, Takako
• Is Part Of: Food & function. Volume 7:Issue 7(2016)
• Page Start: 3056
• Page End: 3063
• Publication Date: 2016-06-01
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/c6fo00088f
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : We have identified the pancreato-protective effects of Lychee Fruit-Derived Polyphenol Mixture, Oligonol, on diabetes. Abstract : We have identified the effects of oligonol, a low-molecular polyphenol derived from lychee fruit, on diabetes-induced pancreatic damage via oxidative stress. Oligonol was orally administered at 10 or 20 mg (kg d) −1 for 10 days to streptozotocin (STZ)-induced diabetic rats, and we assessed the changes in the serum glucose and insulin levels, as well as those of body weight and food and water consumption. In addition, analyses of the weight, insulin content, reactive oxygen species (ROS) level, and western blots of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-4 (Nox-4), p22 phox, p47 phox, phosphor-c-Jun N-terminal kinase (p-JNK), Bax, cytochrome c, caspase 3, pancreatic-duodenal homeobox (PDX-1) and cyclin E were also performed in the pancreas. However, these unfavorable outcomes under diabetes were reversed by oligonol administration. Oligonol treatment led to significantly attenuated histological damage in the pancreas. In conclusion, this study suggests that oligonol protects the pancreas from Bax and PDX-1 via oxidative stress for the prevention or delaying of diabetes mellitus.