Octahedral ruthenium complexes selectively stabilize G-quadruplexes. Issue 52 (6th June 2016)

• Record Type: Journal Article
• Authors: He, Lei; Chen, Xiang; Meng, Zhenyu; Wang, Jintao; Tian, Keyin; Li, Tianhu; Shao, Fangwei
• Is Part Of: Chemical communications. Volume 52:Issue 52(2016)
• Page Start: 8095
• Page End: 8098
• Publication Date: 2016-06-06
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc03117j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Due to the unique three dimensional structures of Ru complexes, strong interactions such as H-bonds between the z -axial ligands and cation channels in G-quadruplexes enabled not only efficient stabilization of G-quadruplexes, but excellent binding resistance against duplex DNA. Abstract : A series of octahedral Ru(ii ) complexes with an x – y planar tetradentate and two trans-z -axis ammonia ligands were synthesized. High stabilization of G-quadruplexes was achieved upon π-stacking with aromatic planar ligands. Unique interaction from z -axis ligands bestowed both excellent binding resistance to duplex DNA and selectivity towards the antiparallel topology.