Octahedral ruthenium complexes selectively stabilize G-quadruplexes. Issue 52 (6th June 2016) - He, Lei
Abstract : Due to the unique three dimensional structures of Ru complexes, strong interactions such as H-bonds between the z -axial ligands and cation channels in G-quadruplexes enabled not only efficient stabilization of G-quadruplexes, but excellent binding resistance against duplex DNA. Abstract : A series of octahedral Ru(ii ) complexes with an x – y planar tetradentate and two trans-z -axis ammonia ligands were synthesized. High stabilization of G-quadruplexes was achieved upon π-stacking with aromatic planar ligands. Unique interaction from z -axis ligands bestowed both excellent binding resistance to duplex DNA and selectivity towards the antiparallel topology.