A mild preparation of alkynes from alkenyl triflates. Issue 24 (31st March 2016)

• Record Type: Journal Article
• Authors: Yang, Xiaowen; Wu, Dimin; Lu, Zhaohong; Sun, Hongbin; Li, Ang
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 24(2016)
• Page Start: 5591
• Page End: 5594
• Publication Date: 2016-03-31
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob00345a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : We report herein a protocol for preparing alkynes from alkenyl triflates at ambient temperature with LiCl as a promoter. Abstract : We report herein a protocol for preparing alkynes from alkenyl triflates. Stoichiometric LiCl promotes this transformation in DMF at ambient temperature. A range of terminal and internal alkynes were obtained smoothly. A one-pot procedure of alkyne formation/Cu-mediated Huisgen cycloaddition was developed, which may find use in synthesizing natural product-based probes.