A mild preparation of alkynes from alkenyl triflates. Issue 24 (31st March 2016) - Yang, Xiaowen
Abstract : We report herein a protocol for preparing alkynes from alkenyl triflates at ambient temperature with LiCl as a promoter. Abstract : We report herein a protocol for preparing alkynes from alkenyl triflates. Stoichiometric LiCl promotes this transformation in DMF at ambient temperature. A range of terminal and internal alkynes were obtained smoothly. A one-pot procedure of alkyne formation/Cu-mediated Huisgen cycloaddition was developed, which may find use in synthesizing natural product-based probes.