Analytical strategies for the detection and quantification of antibiotic residues in aquaculture fishes: A review. (June 2016)

• Record Type: Journal Article
• Authors: Santos, Lúcia; Ramos, Fernando
• Is Part Of: Trends in food science & technology. Volume 52(2016)
• Page Start: 16
• Page End: 30
• Publication Date: 2016-06
• Subjects: Aquaculture -- Antibiotics -- Residue analysis -- LC-MS/MS -- Multi-residue methods; ACN Acetonitrile -- AG Aminoglycosides -- AHD 1-aminohydantoin -- AMOZ 3-amino-5-morpholinomethyl-2-oxazolidinone -- AOZ 3-amino-2-oxazolidinone -- CAP Chloramphenicol -- CCα Decision Limit -- CCβ Detection Capability -- d5-CAP Penta Deuterated Chloramphenicol -- DSPE Dispersive Solid-phase Extraction -- EDTA Ethylenediaminetetraacetic acid -- EU European Union -- FAO Food and Agriculture Organization of the United Nations -- FDA Food and Drug Administration -- FQ Fluoroquinolones -- GC-(NCI)-MS Gas Chromatography-Negative Chemical Ionization-Mass Spectrometry -- GC Gas Chromatography -- GC-ECD Gas Chromatography-Electro Capture Detection -- HILIC Hydrophilic Interaction Chromatography -- HPLC High-performance Liquid Chromatography -- HPLC-PDA High-performance Liquid Chromatography- Photodiode Array Detection -- LC-(ESI)-MS/MS Liquid Chromatography–Electrospray Ionization-Mass Spectrometry in tandem -- LC-(ESI)-MS Liquid Chromatography–Electrospray Ionization-Mass Spectrometry -- LC-(QToF)-MS/MS Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry in tandem -- LC Liquid Chromatography -- LC-FLD Liquid Chromatography-Fluorescence Detection -- LC-MS/MS Liquid Chromatography-Mass Spectrometry in tandem -- LC-MS Liquid Chromatography-Mass Spectrometry -- LC–MSn Liquid Chromatography Multiple-stage Mass Spectrometry -- LOD Limit of Detection -- LOQ Limit of Quantification -- MRL Maximum Residue Limit -- MRM Multi-reaction Monitoring -- MRPL Minimum Required Performance Limit -- MS Mass Spectrometry -- MSn Multiple-stage Mass Spectrometry -- NACA Network of Aquaculture Centres in Asia-Pacific -- OIE World Organization for Animal Health -- o-NBA ortho-nitrobenzaldehyde -- PDA Photodiode Array Detection -- PLE Pressurised Liquid Extraction -- QToF Quadrupole Time of Flight -- QuEChERS Quick, Easy, Cheap, Effective, Rugged, and Safe extraction -- SA Sulfonamides -- SEM semicarbazide -- SPE Solid-phase Extraction -- SPE-LC-(ESI)-MS/MS Solid-phase Extraction coupled to Liquid Chromatography–Electrospray Ionization-Mass Spectrometry in tandem -- TC Tetracyclines -- UHPLC Ultra-high-performance Liquid Chromatography -- UHPLC-MS/MS Ultra-high-performance Liquid Chromatography-Mass Spectrometry in tandem -- UV Ultra-violet -- WHO World Health Organization; Food industry and trade -- Periodicals; Food -- Biotechnology -- Periodicals; 664.005
• DOI: 10.1016/j.tifs.2016.03.015
• Languages: English
• ISSNs: 0924-2244

Abstract

Abstract: Background: Aquaculture is one of the worldwide strategic development fields, and its importance is evident in its significant worldwide growth in the last decades. This growth is associated with the implementation of intensive and semi-intensive production methods, with the use of antibiotics in order to prevent the emergence and spread of infectious diseases in fish. Fluoroquinolones, tetracyclines, and sulfonamides, among others, are widely used for this purpose. This practice constitutes a real public health concern, not only due to the presence of antimicrobial residues in edible tissues, which can cause allergic reactions in hypersensitive individuals, but also due to the emergence of bacterial resistance. Consequently, the European Union's Regulatory Agencies have established maximum residue limits and specific requirements regarding the performance of analytical methods. Scope and approach: This article reviews the most recent analytical methodologies concerning antimicrobial residues in fish, reported in the literature, given emphasis on sample procedures, extraction/purification methods, chromatographic conditions and validation techniques according to legislation. Key findings and conclusions: Liquid chromatography coupled to mass spectrometric detection is used as preferential tool in the analysis of antimicrobial residues in fish. The current analytical strategy is shifting towards multi-residue and multiclass methods, which save time, and surely represent the future trend in this field. The extraction process still represents the limiting factor of any multi-residual method, since it should provide acceptable recovery of all analytes with a broad range of physicochemical properties, and therefore this is probably the step that requires more in-depth research. Highlights: The use of antibiotics in aquaculture leads to the presence of its residues in fish. The most recent methodologies for the analysis of antimicrobials in fish are reviewed. LC-MS/MS is the preferential tool in the analysis of antimicrobial residues in fish. Multi-residue and multiclass analytical methods are the future trend in this field.