The novel dipeptide Tyr-Ala (TA) significantly enhances the lifespan and healthspan of Caenorhabditis elegans. Issue 4 (17th March 2016)

• Record Type: Journal Article
• Authors: Zhang, Z.; Zhao, Y.; Wang, X.; Lin, R.; Zhang, Y.; Ma, H.; Guo, Y.; Xu, L.; Zhao, B.
• Is Part Of: Food & function. Volume 7:Issue 4(2016)
• Page Start: 1975
• Page End: 1984
• Publication Date: 2016-03-17
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/c5fo01302j
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : Food-derived bioactive peptides may have various physiological modulatory and regulatory functions and are now being studied extensively. Abstract : Food-derived bioactive peptides may have various physiological modulatory and regulatory functions and are now being studied extensively. Recently, the novel dipeptide Tyr-Ala was isolated from hydrolyzed maize protein. Tyr-Ala significantly prolonged the lifespan of wild-type Caenorhabditis elegans and extended the nematode healthspan and lifespan during heat/oxidative stress. Compared with its constituent amino acids, Tyr-Ala was more efficient in enhancing stress resistance. Further studies demonstrated that the significant longevity-extending effects of Tyr-Ala on Caenorhabditis elegans were attributed to its in vitro and in vivo free radical-scavenging effects, in addition to its ability to up-regulate stress resistance-related proteins, such as SOD (Superoxide Dismutase)-3 and HSP (Heat Shock Protein)-16.2. Real-time PCR results showed that the up-regulation of aging-associated genes, such as daf-16, sod-3, hsp-16.2 and skn-1, also contributed to the stress-resistance effect of Tyr-Ala. These results indicate that the novel dipeptide Tyr-Ala can protect against external stress and thus extend the lifespan and healthspan of Caenorhabditis elegans . Thereby, Tyr-Ala could be used as a potential medicine in anti-aging research.