Highly oxygenated triterpenoids from the roots of Schisandra chinensis and their anti-inflammatory activities. Issue 2 (1st February 2016)

• Record Type: Journal Article
• Authors: Song, Qiu-Yan; Gao, Kun; Nan, Zhi-Biao
• Is Part Of: Journal of Asian natural products research. Volume 18:Issue 2(2016)
• Page Start: 189
• Page End: 194
• Publication Date: 2016-02-01
• Subjects: Schisandraceae -- Schisandra chinensis -- highly oxygenated triterpenoids -- anti-inflammatory activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2015.1056165
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract : A new highly oxygenated triterpenoid, schinchinenlactone D (1 ), and three known compounds (2 –4 ) were isolated from the roots of Schisandra chinensis . Their structures were determined by combining the spectroscopic analysis with the theoretical computations. The anti-inflammatory activities of compounds1 –4 were evaluated, and compound3 exhibits the most significant activity in the inhibition of NO production with an IC50 value of 10.6 μM.