Safe and efficient membrane permeabilizing polymers based on PLLA for antibacterial applications. Issue 34 (21st March 2016)

• Record Type: Journal Article
• Authors: Li, Zibiao; Chee, Pei Lin; Owh, Cally; Lakshminarayanan, Rajamani; Loh, Xian Jun
• Is Part Of: RSC advances. Volume 6:Issue 34(2016)
• Page Start: 28947
• Page End: 28955
• Publication Date: 2016-03-21
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra04531f
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Highly active antibacterial poly( N, N -dimethylaminoethyl methacrylate)- block -poly(l -lactic acid)- block -poly( N, N -dimethylaminoethyl methacrylate) conjugated with poly(ethylene glycol) (D-PLLA-D@PEG) copolymers were synthesized. Abstract : Poly( N, N -dimethylaminoethyl methacrylate)- block -poly(l -lactic acid)- block -poly( N, N -dimethylaminoethyl methacrylate) conjugated with poly(ethylene glycol) (D-PLLA-D@PEG) copolymers were synthesized. These non-aggregating polymers showed low MIC values against Gram-negative and Gram-positive, including methicillin-resistant Staphylococcus aureus (MRSA), bacteria. The polymers exhibited minimal toxicity and are promising antibacterial agents for biomedical applications.