Safe and efficient membrane permeabilizing polymers based on PLLA for antibacterial applications. Issue 34 (21st March 2016) - Li, Zibiao
Abstract : Highly active antibacterial poly( N, N -dimethylaminoethyl methacrylate)- block -poly(l -lactic acid)- block -poly( N, N -dimethylaminoethyl methacrylate) conjugated with poly(ethylene glycol) (D-PLLA-D@PEG) copolymers were synthesized. Abstract : Poly( N, N -dimethylaminoethyl methacrylate)- block -poly(l -lactic acid)- block -poly( N, N -dimethylaminoethyl methacrylate) conjugated with poly(ethylene glycol) (D-PLLA-D@PEG) copolymers were synthesized. These non-aggregating polymers showed low MIC values against Gram-negative and Gram-positive, including methicillin-resistant Staphylococcus aureus (MRSA), bacteria. The polymers exhibited minimal toxicity and are promising antibacterial agents for biomedical applications.