Aerobic oxidative cyclization of benzamides via meta-selective C–H tert-alkylation: rapid entry to 7-alkylated isoquinolinediones. Issue 24 (15th February 2016)

• Record Type: Journal Article
• Authors: Tang, Shi; Deng, You-Lin; Li, Jie; Wang, Wen-Xin; Wang, Ying-Chun; Li, Zeng-Zeng; Yuan, Li; Chen, Shi-Lu; Sheng, Rui-Long
• Is Part Of: Chemical communications. Volume 52:Issue 24(2016)
• Page Start: 4470
• Page End: 4473
• Publication Date: 2016-02-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c5cc10464e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel copper-catalyzed aerobic oxidative cyclization of benzamides via meta -selective tert -alkylation using AIBN and analogues as radical precursors was described. Abstract : A novel copper-catalyzed aerobic oxidative cyclization of benzamides via meta -selective C–H tert -alkylation using AIBN and analogues as radical precursors was described. This strategy provides an elusive and rapid means to 7- tert -alkylated isoquinolinediones, as well as the construction of tertiary alkyl–aryl C(sp 3 )–C(sp 2 ) bonds with positional selectivity.